Piperacillin-tazobactam 3.375 g IV q6h
Meropenem 500 mg IV q6h
Vancomycin 25 to 30 mg/kg IV x 1 dose, then 15 mg/kg IV q8–12h based on actual body weight
Target trough: 10 to 15 mg/L
Consider capping the loading dose at a maximum of 3,000 mg and maintenance doses at a maximum of 2,000 mg.
Dose adjustment required in renal dysfunction.
MRSA Risk Factors:
History of MRSA infection or colonization
Household contact with a MRSA colonized individual
IV drug use
Recent travel to or residing in an MRSA endemic region or community
Dose adjustment require in renal impairment for all above antimicrobials.