Guidelines
Sepsis of Unknown Source

Sepsis of Unknown Source

Initial Empiric Antimicrobial Therapy

OR

Meropenem 500 mg IV q6h

  • If allergy to penicillin or if known/suspected infection with a multi-drug resistant Gram-negative organism (i.e. ESBL or AmpC producing)

If MRSA risk factors, then ADD:

  • Target trough: 10 to 15 mg/L
  • Consider capping the loading dose at a maximum of 3,000 mg and maintenance doses at a maximum of 2,000 mg.
  • Dose adjustment required in renal dysfunction.
  • History of MRSA infection or colonization
  • Household contact with a MRSA colonized individual
  • IV drug use
  • Homelessness
  • Incarcerated persons
  • Recent travel to or residing in an MRSA endemic region or community

Additional Information

Dose adjustment require in renal impairment for all above antimicrobials.