Varies by setting
Piperacillin-tazobactam 3.375g IV q6h
WITH OR WITHOUT
Clindamycin 900mg IV q8h
cefTRIAXone 2g IV q24h
Metronidazole 500 mg IV q12h
Meropenem 500mg IV q6h
Dose adjustment required for renal dysfunction.
If known/suspected infection with a multi-drug resistant Gram-negative organism (e.g. ESBL/AmpC).
Vancomycin 25 to 30 mg/kg IV x 1 dose, then 15 mg/kg IV q8–12h based on actual body weight
Target trough: 10 to 15 mg/L
Consider capping the loading dose at a maximum of 3,000 mg and maintenance doses at a maximum of 2,000 mg.
Dose adjustment required in renal dysfunction.
MRSA Risk Factors
History of MRSA infection or colonization
Household contact with a MRSA colonized individual
IV drug use
Recent travel to or residing in an MRSA endemic region or community
Blood cultures (2 sets)
Urgent surgical assessment for diagnostic biopsy and/or debridement