Clinical Stability Criteria


Within the first 3 days of therapy, as many as 2/3 of patients will satisfy all clinical stability criteria.

The majority of the remaining 1/3 of patients will satisfy all criteria by day 7 of therapy.


  • Patient is afebrile (e.g. temperature < 38°C) for at least 24 hours

  • Heart rate ≤ 100 beats/minute

  • Respiratory rate ≤ 24 breaths/minute

  • Systolic blood pressure ≥ 90 mmHg

  • Oxygen saturation (SpO2) ≥ 90% on room air (or return to baseline oxygen level for patients receiving long-term oxygen therapy)

  • Normal mental state (compared to baseline)

  • Patient is able to tolerate oral intake

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