High Severity

Notes

Mortality 15-29%

Admission Recommended (Consider ICU)

If microbial cause of infection known, treat accordingly

Empiric Therapy

PLUS

ALTERNATIVELY, CONSIDER

  • If Legionella strongly suspected

  • Exercise caution due to association with C. difficile and MRSA

  • Dose adjustment required for renal impairment

OR

  • Exercise caution due to association with C. difficile and MRSA

IF IN ICU ON Moxifloxacin OR levoFLOXacin, CONSIDER ADDING:

  • Dose adjustment required for renal impairment

Duration

Treat for a minimum of 5 days, and then until the patient meets all clinical stability criteria, then STOP antibiotics

For example:

  • Extrapulmonary infections

  • Empyema

  • Infections caused by P. aeruginosa or S. aureus

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