S. aureus is a ubiquitous organism that colonizes the skin/nares and can cause invasive disease.

Can cause a wide range of clinical syndromes

• Pyogenic skin and soft tissue infection
• Osteomyelitis
• Endocarditis
• Abscess
• Cellulitis
• Pneumonia
• Empyema
• Infection of prosthetic devices
• Others

Toxin mediated diseases:

• Staphylococcal toxic shock syndrome
• Staphylococcal food poisoning
• Staphylococcal scalded skin syndrome

Any localized S. aureus infection can become invasive and lead to bacteremia.