levoFLOXacin
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Dosing Information

  • Usual dosing: 500 mg IV/PO q24h
  • Usual dosing for bacteremia, complicated UTI, pyelonephritis, complicated skin infection, nosocomial pneumonia, intra-abdominal infections, infections due to Pseudomonas spp: 750 mg IV/PO q24h

If usual dose is 500 mg IV/PO q24h

CrCl 20 - 49 mL/min

 500 mg once then 250 mg IV/PO q24h

CrCl <20 mL/min

500 mg IV/PO once then 250 mg IV/PO q48h

Intermittent Hemodialysis (IHD: 3 times/week)

500 mg IV/PO once then 250 mg IV/PO q48h

  • Administer after dialysis when scheduled dose falls on dialysis days

If usual dose is 750 mg IV/PO q24h

CrCl 20 - 49 mL/min

750 mg IV/PO q48h

CrCl <20 mL/min

750 mg IV/PO once then 500 mg IV/PO q48h

Intermittent Hemodialysis (IHD: 3 times/week)

750 mg IV/PO once then 500 mg IV/PO q48h

  • Administer after dialysis when scheduled dose falls on dialysis days