C difficile risk
Oral Bioavailability


200mg PO for 1 dose then 100mg PO q12h

No renal dosing changes required

General Information

  • Lyme Disease

  • Community Acquired Pneumonia

  • Acute exacerbation of COPD

  • Acute uncomplicated bacterial rhinosinusitis

  • Non-invasive Methicillin resistant Staphylococcus aureus infections

  • GI upset and erosive esophagitis: take with food but not with dairy

  • Photosensitivity rash

  • Teeth staining

  • Erosive esophagitis (drink plenty of water with dose)

  • Divalent cations - decreased absorption therefore recommend to space by 2 hours

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

  • Take with food to reduce GI upset.

  • Avoid iron, magnesium, calcium for at least 2 hours before or 2 hours after doxycycline administration.

  • Patient should not lay down for 30 minutes after taking doxycycline (reduces the risk of esophagus irritation).

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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