In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.
If improving renal function, actual CrCl is likely higher than calculated CrCl.
If worsening renal function, actual CrCl is likely lower than calculated CrCl.
Not On Dialysis
Clarithromycin or Clarithromycin XL: 500 mg PO q24h
Intermittent Hemodialysis (IHD: 3 times/week)
Clarithromycin or Clarithromycin XL: 500 mg PO q24h