Cefuroxime

C difficile risk
Medium
Oral Bioavailability
Moderate

Dosing

CrCl >201.5g IV q8h

CrCl >50500mg PO q8-12h

CrCl >20 CrCl 10-19CrCl <101.5g IV q8h1.5g IV q12h 1.5g IV q24h

CrCl 10-49CrCl <10500mg PO q12h500mg PO q24h

IVPO - Cefuroxime axetil1.5g IV q24h Administer dose after dialysis on dialysis days500mg PO q24h Administer dose after dialysis on dialysis days

General Information

  •  Community acquired pneumonia with a macrolide

  •  Intraabdominal infection

  •  Epiglottitis

  •  Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  GI upset

  •  Diarrhea

  •  Abnormal liver enzymes

No significant interactions.

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

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