Amoxicillin-Clavulanate
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl 30-49

  • 500 mg PO q8h

  • 875 mg PO q12h

Dose listed as amoxicillin component Less diarrhea with 875 mg given q12h vs. 500 mg q8h

CrCl 10-29

500 mg PO q12h

Dose listed as amoxicillin component Do not use 875 mg tablets if CrCl less than 30 mL/min

CrCl <10

500 mg PO q24h

Dose listed as amoxicillin component Do not use 875 mg tablets if CrCl less than 30 mL/min

500 mg PO q24h

Dose listed as amoxicillin component Administer dose after dialysis on dialysis days