C difficile risk
Oral Bioavailability


500mg-1g q8h

CrCl 30-49CrCl 10-29CrCl <10500mg-1g PO q8h 500mg PO q12h500mg PO q24h

500 mg q24h

Administer dose after dialysis on dialysis day

General Information

  • Treatment of infections due to beta-hemolytic streptococcus (Streptococci group A/B/C/G) such as skin infections, pharyngitis

  • Community acquired pneumonia

  • Acute exacerbation of COPD

  • Bacterial sinusitis

  • Dental infections or prophylaxis prior to dental procedures when indicated

  • Enterococcus faecalis infections

  • Allergy/rash (immediate or delayed), especially in setting of mononucleosis infection

  • Cytopenias

Allopurinol - increased rash

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: NOT Therapeutic

Biliary penetration: Therapeutic

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