Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia
Pregnancy: Compatible.
Breastfeeding: Compatible.
Allergy/rash (immediate or delayed), cytopenias- esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes
Incr. levels of methotrexate
Higher doses required for antipseudomonal coverage (4.5 g IV q6h)
Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor
Average serum half life: 1.0
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic