Antimicrobials
Piperacillin-Tazobactam

Piperacillin-Tazobactam

Medium
N/A

Dosing

General Information

Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia

Pregnancy: Compatible.

Breastfeeding: Compatible.

Allergy/rash (immediate or delayed), cytopenias- esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes

Incr. levels of methotrexate

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic