Antimicrobials
Cloxacillin

Cloxacillin

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

2g IV q4-6h

General Information

Treatment of MSSA infections

Allergy (immediate or delayed), Phlebitis at injection site in a peripheral vein, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes

Can increase methotrexate levels

Decrease mycophenolate levels

Must use higher doses in bacteremia due to highly protein bound

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic