Antimicrobials
Clindamycin

Clindamycin

High
Excellent

Dosing

General Information

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

Pregnancy: 

  • Likely compatible.
  • Very limited studies raises possible concern for birth defects.
  • Avoid in 1st trimester if possible.

Breastfeeding: 

  • Compatible.

None specific - monitor for diarrhea.

High risk of Clostridium difficile infection

Muscle relaxants, e.g., atracurium, baclofen, diazepam

St. Johns Wort

Antimicrobial class: Lincosamide

Average serum half life: 2.4

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor