Antimicrobials
Ceftriaxone

Ceftriaxone

High
N/A

Dosing

General Information

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

Empiric therapy of hospitalized community or nursing home acquired pneumonia in combination with a macrolide

Empiric therapy of spontaneous bacterial peritonitis

Empiric treatment of pyelonephritis

Pregnancy:

  • Compatible.
  • Consider alternative to ceftriaxone (ie. cefotaxime) at the time of delivery (particularly in preterm delivery) to minimize exposure to newborn.

Breastfeeding:

  • Compatible.

Allergy/rash (immediate or delayed).

Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities

Pseudocholelithiasis- unclear clinical significance - uncommonly symptomatic, but frequently by ultrasound gallbladder sludge

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Average serum half life: 8.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic