Primary syphilis: Ulcer of chancre at the infection site

Secondary syphilis (selected symptoms): Skin rash, mucocutaneous lesions, lymphadenopathy

Early latent syphilis: If during the past year preceding the diagnosis:

• Documented seroconversion or >14 fourfold or greater increase in nontreponemal test titers
• Unequivocal symptoms of primary or secondary syphilis
• Sex partner documented to have primary, secondary, or latent syphilis

Latent syphilis: Syphilis characterized by seroreactivity without other evidence of primary, secondary, or tertiary disease

Tertiary syphilis: Cardiac, gummatous lesions, tabes dorsalis, general paresis