Max: 2,000 mg/dose
PLUS
If concerned/risk factors for Listeria monocytogenes ADD
Max: 2 g/dose
S. agalactiae (Group B streptococcus): 14 - 21 days
N. meningitidis: 7 days
S. pneumoniae: 10 - 14 days
Listeria sp: At least 21 days and 2 weeks from last positive culture (whichever is longer)
Gram negative: In the neonate, 2 weeks beyond the first sterile CSF culture or ≥ 3 weeks, whichever is longer
Infectious Diseases Consult is recommended
Narrow empiric therapy based upon culture results
If unable to obtain LP prior to beginning antibiotics, consider CNS Biofire (multiplex PCR testing) as PCR will remain positive for some time after antibiotics/antivirals have been started
Max dose provided for drugs with therapeutic drug monitoring can be higher than provided once individual labs available
More information available IDSA Guidelines or ESCMID Guidelines