Levels not routinely performed, but some evidence suggests troughs > 0.25 mg/L decrease likelihood of prophylaxis failure and levels > 0.5 mg/L are associated with treatment success
Toxicity
Troughs > 1 mg/L are associated with increased rates of toxicity, especially hepatic toxicity
Solution and capsules are not equivalent. Oral solution preferred due to increased absorption
Hydroxypropyl-β-cyclodextrin in the oral solutions increases the bioavailability compared to the capsules
Oral solution should be taken under fasting conditions
100 mg capsules should be taken with food and acidic pH for optimal absorption (65 mg capsules have different recommendations - refer to Lexicomp for more information if considering use)