Targeted therapy of ESBL infections and other resistant gram negative infections
Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity
Weekly CBC with differential, chemistries, renal and hepatic function
Please refer to Lexicomp for more information
Valproic acid - carbapenems decrease valproate levels and may decrease seizure threshold
Please refer to Lexicomp for more information
Antimicrobial class: Carbapenem
Average serum half life:
Infants 3 months and older, and children: 2.5hrs
Adolescents and Adults: 4 hrs
Does not achieve reliable CNS concentrations
Route of Elimination:
Non-CYP-mediated hydrolysis to inactive metabolite
Urine (80% (38% as unchanged drug)) and feces (10%)