Monitor creatinine at least 3 times/week. Discontinue if any signs of ototoxicity.
For Multiple daily dosing: Target Peak 4-10 ug/mL, Trough 1-2 ug/mL.
For Once daily: Target Trough <1 ug/mL.
NB: Trough level is 0-60min before a dose (usually pre-4th), and peak is 30-60min after dose infused (usually post-3rd).
In critically ill patients, check peak level after the 1st dose as volume of distribution and renal function may change rapidly.