Antimicrobials
Aciclovir

Aciclovir

None
Moderate

Spectrum of Activity

Dosing

General Information

Therapy for herpesviral infections (HSV and VZV) including encephalitis.

Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.

Follow SCr as appropriate.

Check urine for crystals if AKI suspected.

  • GI upset
  • Phlebitis
  • Increased SCr
  • AKI from crystal nephropathy

Mycophenolate can increase the acyclovir concentration.

May diminish efficacy of zoster or varicella vaccine.

For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.

Antimicrobial class: Antiviral. Nucleoside analogue.

Pregnancy category: B

Average serum half life: 3 hours

Urine penetration: Therapeutic

CSF penetration: Therapeutic