Diabetic Foot Infection (DFI)
All dosages assume normal renal and hepatic function
Definitive antimicrobial therapy should be based on deep tissue culture results
Empiric Antimicrobial Therapy
Superficial: Limited in size and depth, erythema >0.5cm to ≤2cm around the ulcer
Deep: Involving structures deeper than skin and subcutaneous tissues (e.g. abscess, osteomyelitis, septic arthritis, fasciitis)
Limb-threatening: Systemic toxicity (i.e. hypotension), critical ischemia (i.e. wet gangrene), ICU admission, or qSOFA score ≥2
Stevens DL, Bisno AL, Chambers HF et al. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clin Infect Dis 2014 59: e10-52.
Pichichero ME. Cephalosporins can be prescribed safely for penicillin-allergic patients. J Fam Pract 2006 55: 106-112.
Lipsky BA, Berendt AR, Cornia PB, et al 2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infections. Clin Infect Dis 2012; 54: 132 173.