Antimicrobials
Meropenem

Meropenem

Restricted

High
N/A
$$$

Dosing

General Information

  • Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY
  • Approved Indications:
    1. Documented infection with P. aeruginosa
    2. Penicillin AND cephalosporin allergies
    3. High suspicion for ESBLs or P. aeruginosa
    4. Peds ONLY - Hemodynamically unstable
    5. Peds ONLY - Fever/neutropenia & typhlitis
    6. Peds ONLY - Suspected NEC - severe

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

  • Immediate and delayed-type allergy
  • GI disturbance
  • Cytopenias, positive Coombs
  • Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic