Antimicrobials
Linezolid

Linezolid

Low
Excellent
IV:$$ PO:$

Dosing

General Information

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. Documented VRE from a non-urine source
  2. S. aureus with high vancomycin MIC (2 mcg/ml)
  3. Documented vancomycin allergy - NOT Red Man's
  4. Vancomycin failure of therapy (≥ 5 days)
  5. Unable to reach target vancomycin trough
  6. PO Therapy - MRSA or VRE (non-urine)
  • Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia
  • Covers MRSA and VRE
  • CBC at least once/week
  • Visual testing for therapy >3 months or if symptoms develop on therapy
  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis
  • Myelosuppression (usually with >2 weeks therapy) - reversible
  • Peripheral/optic neuropathy with prolonged courses
  • SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome
  • Rifampin decreases linezolid levels

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic