Guidelines
Vancomycin Nomogram

Vancomycin Nomogram

Note

This nomogram is only valid for patients:

  • Weighing less than 120 kg, and
  • With a serum creatinine of less than 200 mcmol/L
    • See “Vancomycin Dosing in Renal Impairment” section for dosing in patients with renal impairment

Vancomycin Nomogram

Rationale for Lower Vancomycin Trough Target *NEW*

Most recent evidence recommends targeting vancomycin steady-state serum trough concentrations of 10 to 15 mg/L for most infections.

Previously recommended vancomycin trough concentrations between 15 to 20 mg/L for serious infections such as bacteremia, are NO LONGER RECOMMENDED due to increased risk of acute kidney injury (AKI) and lack of clear clinical benefit.