Beta-lactam Allergy - Safe Antibiotic Selection
Allergy Types

Allergy Types

Allergy Types

Mediated by IgE antibodies Onset usually within 1 hour (up to 24h) Cross-reactivity information useful Skin Testing useful

Mediated by IgG or IgM antibodies Onset usually >72 hours (up to 14 days) Reaction is drug specific Cross-reactivity information is not useful Offending drug is contraindicated

Mediated by antigen-antibody complexes Onset usually >72 hours (up to 14 days) Cross-reactivity information is lacking If severe (e.g. AIN), all beta-lactams are considered contraindicated unless guided by an expert

Mediated by T-cells Onset usually >72 hours (up to 3-4 weeks) Cross-sensitivity is possible but not predictable by skin testing or oral challenge If severe (e.g. SJS), all beta-lactams are considered contraindicated unless guided by an expert