Colistin
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not on Dialysis

0 - 10 eGFR

150 mg IV q36h, or if less than 60 kg, 1.5-2.5 mg/kg IV q36h

10 - 50 eGFR

150 mg IV q24h, or if less than 60 kg, 2.5 mg/kg IV q24h

50+ eGFR

150 mg IV q12h, , or if less than 60 kg, 2.5 mg/kg IV q12h

Intermittent Dialysis

On days with no HD, give 52.5 mg IV q12h; on dialysis days, give 75 mg IV during last hour of dialysis and 75 mg 12 hours later

Continuous Dialysis

150 mg IV q24h, or if less than 60 kg, 2.5 mg/kg IV q24h