Oseltamivir
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (CrCL)

CrCL = 31 to 60 ml/min

Treatment: 30mg PO BID x 5 days

Prophylaxis: 30mg PO daily x 10 days for exposures or for duration of outbreak

CrCL = 10 to 30 ml/min

Treatment: 30mg PO daily x 5 days

Prophylaxis: 30mg PO every OTHER day x 10 days for exposures or for duration of outbreak

CrCL < 10 ml/min

Treatment: 75mg PO x 1 dose for the duration of illness

Prophylaxis: No data available

Intermittent Dialysis

Treatment: 75mg PO qHD over a 5 day period

Prophylaxis: No data available

Peritoneal Dialysis

Treatment: 75mg PO x 1 dose for duration of illness

Prophylaxis: 30mg before dialysis, then 30mg weekly for exposures or for duration of outbreak