In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.
If worsening renal function, actual GFR is likely lower than calculated.
If improving renal function, actual GFR is likely higher than calculated eGFR.
Not On Dialysis (CrCL)
Treatment: 30mg PO BID x 5 days
Prophylaxis: 30mg PO daily x 10 days for exposures or for duration of outbreak
Treatment: 30mg PO daily x 5 days
Prophylaxis: 30mg PO every OTHER day x 10 days for exposures or for duration of outbreak
Treatment: 75mg PO x 1 dose for the duration of illness
Prophylaxis: No data available
Intermittent Dialysis
Treatment: 75mg PO qHD over a 5 day period
Prophylaxis: No data available
Peritoneal Dialysis
Treatment: 75mg PO x 1 dose for duration of illness
Prophylaxis: 30mg before dialysis, then 30mg weekly for exposures or for duration of outbreak