Chlamydia trachomatis
Amoxicillin

Amoxicillin

Low
Excellent
See below under General Info

Dosing

General Information

Hospital Formulary Status Yes (PO solid, PO powder for susp)

In-Hospital Cost will be updated

PharmaCare Formulary Status Yes (PO solid, PO susp)

SA None

PharmaCare Coverage 250mg PO - $0.0726/cap 500mg PO - $0.1413/cap 125mg PO chew - $0.5507/tab 250mg PO chew - $0.8113/tab 125mg/5ml PO susp recon - $0.0380/ml 250mg/5ml PO susp recon - $0.0583/ml

Outpatient Cost 250mg PO - $0.08-0.30/cap 500mg PO - $0.15-0.89/cap 125mg PO chew - $0.55-0.61/tab 250mg PO chew - $0.81-0.89/tab 125mg/5ml PO susp recon - $0.038-0.042/ml 250mg/5ml PO susp recon - $0.058-0.064/ml

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections, urinary tract infection, dental infections.

Allergic reaction (PO)

  • IgE-mediated
  • sx: pruritus, flushing, urticaria, angioedema, wheezing, laryngeal edema, hypotension, and/or anaphylaxis
  • sx usually appear within 4 hrs of administration but may begin within mins

Serum sickness (PO)

  • late allergic reaction
  • sx: fever, rash, adenopathy, arthritis and glomerulonephritis
  • associated with circulating immune complexes

Rash (PO)

  • includes morbilliform rash, erythema multiforme, SJS, exfoliative dermatitis, toxic epidermal necrolysis and vasculitis
  • sx: photosensitivity, skin lesions, mucosal membrane ulceration, erythema, scaling, palpable purpura and/or positive Nikolsky's sign

Note: EBV-related rash - not an allergy

  • morbilliform rash, occurring 48 hrs to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus, does not appear to be a true drug allergy

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1.0 hr

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic