Hospital Formulary Status Yes (parenteral inj, powder for compounding)
In-Hospital Cost will be updated
PharmaCare Formulary Status Yes (parenteral inj, powder for compounding)
Special Authority None
PharmaCare Coverage 50mg powder for soln - $95.85/vial
Outpatient Cost 50mg powder for soln - $95.85-105.44/vial
Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity
Induction therapy for dimorphic fungii (cocci, blasto, histo)
Frequency depends on course, but daily reasonable during initiation
Careful attention to electrolyte and fluid status with boluses (usually 500ml) of NS before and after infusion
Nephrotoxicity (IV)
Infusion-related reactions (IV)
Phlebitis (IV)
Electrolyte abnormalities (IV)
Anemia (IV)
Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy
Digoxin - increased digoxin toxicity with hypokalemia
Antimicrobial class: Antifungal, Polyene
Pregnancy category: B
Average serum half life: 24.0 hr
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic