Coadministration with zidovudine is associated with high rates of neutropenia.
Nevirapine-containing ART regimens are associated with reduced amodiaquine exposure.
Efavirenz coadministered with amodiaquine has been associated with hepatotoxicity.
Antimicrobial class: 4-aminoquinoline
Average serum half life: Approximately 9 days in children with malaria
Metabolism: Rapid first-pass hepatic metabolism to the biologically active metabolite desethylamodiaquine (DeAQ) mediated by cytochrome P450 (CYP2C8).