Antimicrobials
Doxycycline

Doxycycline

Low
Excellent
$0.20/day

Spectrum of Activity

Dosing

General Information

  • Lyme disease
  • Skin and soft tissue infection
  • Methicillin resistant staphylococcus aureus infections
  • GI upset (take with food to avoid)
  • Erosive esophagitis (drink plenty of water with dose)
  • Photosensitivity rash
  • Teeth staining (risk much lower than with other tetracyclines)

Divalent cations- decreased absorption therefore recommended to space by 2 hours.

Take with food to reduce GI upset. Avoid iron, magnesium, calcium for at least two hours before or two hours after doxycycline administration.

Contraindicated in pregnancy and not routinely recommended in children <8 years of age due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth (much lower than other tetracyclines)

Antimicrobial class: Tetracycline

Average serum half life:

  • No data for pediatrics.
  • Adults: 12 to 15 hours (usually increases to 22 to 24 hours with multiple dosing)

Route of Elimination: In the urine (23%) and feces (30%)