Divalent cations- decreased absorption therefore recommended to space by 2 hours.
Take with food to reduce GI upset. Avoid iron, magnesium, calcium for at least two hours before or two hours after doxycycline administration.
Contraindicated in pregnancy and not routinely recommended in children <8 years of age due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth (much lower than other tetracyclines)
Antimicrobial class: Tetracycline
Average serum half life:
Route of Elimination: In the urine (23%) and feces (30%)