1-2g IV q8h
2g IV q8h
CrCl greater than 50 mL/minCrCl 31-50 mL/minCrCl 16-30 mL/minCrCl less than or equal to 15 mL/minNo change1-2g IV q12h1-2g IV q24h500mg-1g IV q24h
Dosing based on assumption of 3 times weekly dialysis500mg-1g IV q24h OR 1-2g IV q48-72h
Dose after HD on dialysis days
PeritonitisGeneral1-2g IP q24h in one exchange (in the long dwell - greater than 6 hours)
Consider loading dose of 3g1g IV q24h
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.
Allergy (immediate and delayed).
Note potential cross-reactivity with aztreonam based on side chain.
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic
Biliary penetration: Moderate