Antimicrobials
Ceftazidime (Fortaz)

Ceftazidime (Fortaz)

Restricted
C difficile risk
High
Oral Bioavailability
N/A
Cost
~$20.00/day

Dosing

1-2g IV q8h

2g IV q8h

CrCl greater than 50 mL/minCrCl 31-50 mL/minCrCl 16-30 mL/minCrCl less than or equal to 15 mL/minNo change1-2g IV q12h1-2g IV q24h500mg-1g IV q24h

Dosing based on assumption of 3 times weekly dialysis500mg-1g IV q24h OR 1-2g IV q48-72h

Dose after HD on dialysis days

PeritonitisGeneral1-2g IP q24h in one exchange (in the long dwell - greater than 6 hours) 

Consider loading dose of 3g1g IV q24h

General Information

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins.

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate