Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites.
Monitor QTc in patients with increased risk.
QTc prolongation
Dysglycemia
Tendinopathy and rupture
GI upset
Rash
Retinal detachment
CNS toxicity including confusion, psychosis
Weakness exacerbation in myasthenia gravis
CYP1A2 inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption.
Cyclosporine - Increased levels of cyclosporine.
Warfarin - Increased INR.
Methadone - Lowered seizure threshold.
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Moderate
Biliary penetration: Therapeutic