Antimicrobials
Ciprofloxacin (Cipro)

Ciprofloxacin (Cipro)

High
Excellent
PO ~$0.20/day; IV ~$6.00/day

Dosing

General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites.

Monitor QTc in patients with increased risk.

  • QTc prolongation

  • Dysglycemia

  • Tendinopathy and rupture

  • GI upset

  • Rash

  • Retinal detachment

  • CNS toxicity including confusion, psychosis

  • Weakness exacerbation in myasthenia gravis

CYP1A2 inhibitor - Multiple interactions possible.

QTc prolongation - Increased risk with other agents that prolong QTc.

Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption.

Cyclosporine - Increased levels of cyclosporine.

Warfarin - Increased INR.

Methadone - Lowered seizure threshold.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic