Tigecycline (Tygacil)

Tigecycline (Tygacil)

C difficile risk
Oral Bioavailability


100mg IV load on day 1, then 50mg IV q12h

No dosage adjustment necessary

100mg load on day 1, then 25mg IV q12h

No dosing adjustment necessary

Poorly dialyzed

No supplemental dose or dosage adjustment neccessary

Unlikely to be dialyzed

No dosage adjustment necessary

This medication is currently not on hospital formulary - please contact pharmacy if it is needed.

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

  • Avoid or use with caution in patients with tetracycline reactions
  • GI side effects very prominent with significant nausea and vomiting
  • Tetracycline related adverse events: photosensitivity, acute pancreatitis
  • Rash, abnormal liver enzymes

Oral contraceptives less effective.

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Lung penetration: Therapeutic

Biliary penetration: Therapeutic