100mg IV load on day 1, then 50mg IV q12h
No dosage adjustment necessary
100mg load on day 1, then 25mg IV q12h
No dosing adjustment necessary
No supplemental dose or dosage adjustment neccessary
Unlikely to be dialyzed
This medication is currently not on hospital formulary - please contact pharmacy if it is needed.
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Oral contraceptives less effective.
Requires Infectious Disease consultation.
Documented safety concerns in bacteremia especially.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Lung penetration: Therapeutic
Biliary penetration: Therapeutic