Antimicrobials
Amoxicillin (Amoxil)

Amoxicillin (Amoxil)

C difficile risk
Low
Oral Bioavailability
Excellent
Cost
~$0.03/day

Dosing

Usual indicationsCertain indications500-1000mg PO TID1000mg PO BID

CrCl greater 30 mL/minCrCl 10-30 mL/minCrCl less than 10 mL/minIntermittent HemodialysisPeritoneal DialysisNo change250-500mg PO q12h250-500mg PO q12-24h250-500mg PO q12-24h

Take after dialysis on dialysis days or give extra dose after dialysis250-500mg PO q12h

CrCl greater than or equal to 30 mL/minCrCl 10 - 29 mL/minCrCl less than 10 mL/minIntermittent HemodialysisPeritoneal DialysisNo change500mg PO q12h500mg PO q12-24h500mg PO q12-24h 

Take after dialysis on dialysis days or give extra dose after dialysis500mg PO q12h

CrCl greater than/equal to 30 mL/minCrCl 10-30 mL/minCrCl 0-10 mL/minIntermittent HemodialysisPeritoneal DialysisNo change1000mg PO q12h500mg PO q12h500mg PO q12h

Take after dialysis on dialysis days or give extra dose after dialysis500mg PO q12h

General Information

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infections.

  • Allergy/rash (immediate or delayed)
  • Note EBV related rash
  • Cytopenias

Allopurinol - increased rash.

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor (except when meninges are inflamed)

Biliary penetration: Therapeutic