Liver function in patients with preexisting hepatic dysfunction, and in all patients as clinically indicated; renal function; signs/symptoms of HF.
For invasive aspergillosis (treatment or prolonged prophylaxis):
Oral solution and capsule dosage should NOT be used interchangeably.
Administer capsules immediately after a full meal for maximal absorption. Administering with acidic beverage (i.e. cola, orange or cranberry juice) can increase absorption. If patient is on a PPI, administer with acidic beverage.
Oral solution should be taken on an empty stomach (1 hour before or 2 hours after meals) for maximal absorption.
Antimicrobial class: Triazole antifungal
Pregnancy category: C
Average serum half life: 35-40 hours
Biliary penetration: Therapeutic
CSF penetration: Low
Lung penetration: Therapeutic
Urine penetration: Low