Vancomycin IV

Vancomycin IV



General Information

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections.

  • Collect trough 0-1h before 3rd dose if abnormal/fluctuating renal function.
  • Target trough 15-20mcg/mL for most serious infections, 20-25mcg/mL for meningitis.
  • If trough low, increase dose (do not exceed 2g/dose) OR decrease dosing interval.
  • If trough >20, increase dosing interval or decrease dose.
  • Nephrotoxicity
  • Cytopenias
  • Rash including Stevens-Johnson Syndrome
  • Vancomycin infusion reaction (histamine release - slow down infusion)
  • Aminoglycosides may potentiate nephrotoxicity.
  • May enhance neuromuscular blockade of NM blocking agents.
  • Careful with concomitant nephrotoxins.

Antimicrobial class: Glycopeptide

Pregnancy category: C

Average serum half life: 8 hours

Biliary penetration: Moderate

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic