Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection.
Creatine kinase weekly.
Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.
Higher doses used for endovascular infection.
Recommend Infectious Disease Consult.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Antimicrobial class: Cyclic Lipopeptide
Pregnancy category: B
Average serum half life: 9 hours
CSF penetration: Poor
Lung penetration: Poor
Urine penetration: Therapeutic