Doxycycline

Restricted
C difficile risk
Low
Oral Bioavailability
Excellent
Cost
$40/day

Dosing

DosingIV to PO Conversion100mg IV q12h (max: 200 mg/day)100 - 200 mg IV q12h to 100 - 200 mg po q12h

General Information

Pediatrics: Children >8 years of age

Take with food to reduce GI upset. Avoid iron, magnesium, calcium for at least two hours before or two hours after doxycycline administration.

Contraindicated in pregnancy and not routinely recommended in children <8 years of age due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth (much lower than other tetracyclines)

VRE UTI Usage Better activity against Enterococcus spp.compared to tetracycline (at one institution 40% and 90% of VRE urine isolates were sensitive to tetracycline and doxycycline, respectively); Good activity against VRE biofilm

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