Tobramycin

C difficile risk
Low
Oral Bioavailability
N/A
Cost
$15/day

Spectrum Of Activity

Dosing

PNA-days 0 - 7PNA-days 8 - 28PNA-days 29+ 5 mg/kg/dose IV q48h4 mg/kg/dose IV q36h4 mg/kg/dose IV q24h

PNA-days 0 - 7PNA-days 8+ 4.5 mg/kg/dose IV q36h4mg/kg/dose IV q24h

4 mg/kg/dose IV q24h

Preferred dosing strategy for patients requiring gram-negative antimicrobial activity unless patient falls into one of the exceptions categoriesThe following dosing recommendations should not be applied in: Endocarditis, pregnancy, myasthenia gravis, mycobacterium infections such as tuberculosis, and burn patients

CrCl ≥ 90 mL/minCrCl 50-89 mL/minCrCl 25-49 mL/minCrCl < 25 mL/min or hemodialysis patient7 mg/kg IV q24hr5 mg/kg IV q24hr2.5 mg/kg IV q24hrContact clinical pharmacist

General Information

Cockroft-Gault equation: CrCl (mL/min) = [(140 – Age) x weight†/(72 x Scr)] x (0.85 if female)

If total body weight (TBW) > 30% of ideal body weight (IBW), use adjusted body weight (ABW) If TBW < IBW, use TBW

ABW = IBW + 0.4 x (TBW – IBW)

IBW:

  • Males = 50 kg + 2.3 kg for every inch > 60 inches

  • Females = 45 kg + 2.3 kg for every inch > 60 inches

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