Antimicrobials
Pyrazinamide

Pyrazinamide

Dosing

Daily Dose:30-40 mg/kg/day

Maximum Daily dose: 2000 mg

Dosing Frequency: PO once daily

General Information

Patients who consume alcohol or have viral hepatitis, drug induced liver injury, HIV

Should only be used for the first 2 months of therapy

  • Most common cause of drug induced hepatotoxicity and rash in patients with initial 4 drug therapy for tuberculosis.

  • Arthralgias in 10%

In combination with INH or rifampin, increased risk of hepatotoxicity

Treatment of TB disease

Liver enzymes at baseline and if symptoms in children

500 mg scored tablet