Spectrum of Activity


General Information

Patients who consume alcohol or have viral hepatitis, drug induced liver injury, HIV

Should only be used for the first 2 months of therapy

  • Most common cause of drug induced hepatotoxicity and rash in patients with initial 4 drug therapy for tuberculosis.
  • Arthralgias in 10%

In combination with INH or rifampin, increased risk of hepatotoxicity

Treatment of TB disease

Liver enzymes at baseline and if symptoms in children

500 mg scored tablet