Antimicrobials
Levofloxacin

Levofloxacin

Spectrum of Activity

Dosing

General Information

  • Very high risk of C. difficile colitis and subsequent colonization with pathogens resistant to the fluoroquinolone class.
  • QTc prolongation
  • Tendinopathy and tendon rupture
  • Aortic dissection, aneurysm
  • CNS toxicity including confusion and psychosis
  • Opiate screen false positives
  • Hypo/hyperglycemia
  • Peripheral neuropathy
  • Thrombocytopenia
  • QTc prolongation - Increased risk with other agents that prolong QTc
  • AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours
  • Monitor INR with warfarin

Appropriate use includes treatment of serious gram-negative infections when other antimicrobials are unsuitable due to resistance profile.

Oral bioavailability is ~99% and oral route should be used if there is a functioning gastrointestinal tract.

Concentration: 50 mg/mL. NOTE: extemporaneous compound may not be available at all community pharmacies

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

  • 250 mg
  • 500 mg
  • 750 mg

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.