Sulfamethoxazole - Trimethoprim (TMP-SMX)

Sulfamethoxazole - Trimethoprim (TMP-SMX)

Spectrum of Activity


General Information

  • Steven's Johnson syndrome, Toxic epidermal necrolysis
  • DRESS (Fever, Rash, Eosinophilia, internal organ involvement (e.g. hepatitis)
  • Interstitial nephritis/ nephrotoxicity
  • Elevated liver enzymes
  • Hyperkalemia

It is inappropriate to treat AOM or community-acquired pneumonia with TMP-SMX because of high levels of resistance of S. pneumoniae to TMP-SMX.

Concentration: 8 mg/mL TMP

Taste: Very good

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

  • 80 mg TMP(SS)
  • 160 mg TMP(DS)

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.