30 mg/kg/day (of amoxicillin component) divided Q12H
15 mg/kg/day (of amoxicillin component) once daily
Daily Dose: 45 - 60 mg/kg/day of amoxicillin component
Maximum Daily Dose: 4000 mg/day amoxicillin component
Dosing Frequency: PO divided TIDFor a child weighing < 35 kg
Use suspension. Specify 400 mg/5mL suspension of 7:1 formulation to minimize risk of diarrhea.For a child weighing ≥ 35 to < 40 kg
Use 500 mg tablets PO TID or suspension. Specify 400 mg/5mL suspension of 7:1 formulation to minimize risk of diarrhea.For a child weighing ≥ 40kg
Use 875mg tablet PO TID or suspension. Specify 400mg/5mL suspension or 7:1 formulation to minimize risk of diarrhea
If patient unable to swallow whole tablets, tablet may split in half. Tablets may also be crushed and mixed with a small amount of water, milk or food if taken immediately.
Note dosing is for 5:1 formulation only
< 3 months: 25 mg/kg/dose IV every 12 hours
≥ 3 months: 25 mg/kg/dose IV every 8 hours
Maximum dose: 1000mg
Hepatotoxicity (cholestatic or mixed ) due to clavulanate
Diarrhea 9% (due to clavulanate component)
Non-allergic rash
Cytopenias with prolonged use
Oral
Prophylaxis or treatment of a human or animal bite wound
Children with AOM (BID or preferably TID) who have taken Amoxicillin in the prior 30 days
Persistent or AOM not responding to Amoxicillin therapy
Chronic sinusitis as provided coverage for possible beta-lactamase positive H. influenzae and M. catarrhalis and/or S. aureus
IV
Empiric prophylaxis and treatment of animal and human bite wounds
Empiric treatment of chronic sinusitis requiring IV therapy as an alternative to cefuroxime
Treatment of pneumonia in patients with suspected or proven Moraxella catarrhalis or H. influenzae resistant to ampicillin
Treatment of complicated appendicitis in patients who have received aminoglycosides ≥ 8 days and who do not have resistant pathogens isolated
Concentration: 400 mg/5 mL of 7:1 formulation
Taste: Good
Not all strengths of oral liquids are listed nor be available on the CHEO Formulary
500 mg amoxicillin component
875 mg amoxicillin component
Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary
