Antimicrobials
Azithromycin

Azithromycin

Dosing

10 mg/kg/dose IV/PO once daily

20 mg/kg/day PO once daily for 3 days

Less than 1 month: 10 mg/kg/day PO for 5 days

Daily Dose: 10 mg/kg/day

Maximum Daily Dose: 500 mg/day

Dosing Frequency: IV divided q24h

Used for CAP due to Mycoplasma or Chlamydophila

Daily Dose: 10 mg/kg/day PO on day 1 then 5 mg/kg/day PO for days 2 - 5

Maximum Daily Dose: 500 mg/day PO for day 1, 250 mg/day PO for days 2 - 5

Dosing Frequency: PO divided Once Daily

Less than 6 months: 10 mg/kg/day PO for 5 days

Greater than 6 months: 10 mg/kg/day PO on day 1 then 5 mg/kg/day for days 2- 5

Maximum Daily Dose:

500 mg/day PO for day 1

250 mg/day PO for days 2 - 5

Dosing Frequency: divided Once Daily

Note this should always include concurrent treatment for N. gonorrhoeaeDaily Dose: 12 - 15 mg/kg/dose as a single dose

Maximum Daily Dose: 1 g/dose

Dosing Frequency: PO as a single dose

General Information

  • Prolongation of QTc interval

  • Diarrhea

  • Pyloric stenosis (infantile hypertrophic pyloric stenosis, IHPS) has been reported with erythromycin and azithromycin in infants less than 6 weeks

While less risk of interaction compared to other macrolides, several potential CYP450 interactions may occur; consult a pharmacist for for more details.

Avoid concurrent use with other drugs that prolong QTc

Monitor for signs or symptoms of infantile hypertrophic pyloric stenosis (IHPS) if infant under 6 weeks of life.

Azithromycin is still the drug of choice for treatment or prophylaxis of pertussis as the risk of developing severe pertussis outweighs the potential risk of IHPS.

Concentration: 40 mg/mL

Taste: Bitter taste

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

  • 250 mg

  • 600 mg

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.