10 mg/kg/dose IV/PO once daily
20 mg/kg/day PO once daily for 3 days
Less than 1 month: 10 mg/kg/day PO for 5 days
Daily Dose: 10 mg/kg/day
Maximum Daily Dose: 500 mg/day
Dosing Frequency: IV divided q24h
Used for CAP due to Mycoplasma or Chlamydophila
Daily Dose: 10 mg/kg/day PO on day 1 then 5 mg/kg/day PO for days 2 - 5
Maximum Daily Dose: 500 mg/day PO for day 1, 250 mg/day PO for days 2 - 5
Dosing Frequency: PO divided Once Daily
Less than 6 months: 10 mg/kg/day PO for 5 days
Greater than 6 months: 10 mg/kg/day PO on day 1 then 5 mg/kg/day for days 2- 5
Maximum Daily Dose:
500 mg/day PO for day 1
250 mg/day PO for days 2 - 5
Dosing Frequency: divided Once Daily
Note this should always include concurrent treatment for N. gonorrhoeaeDaily Dose: 12 - 15 mg/kg/dose as a single dose
Maximum Daily Dose: 1 g/dose
Dosing Frequency: PO as a single dose
Prolongation of QTc interval
Diarrhea
Pyloric stenosis (infantile hypertrophic pyloric stenosis, IHPS) has been reported with erythromycin and azithromycin in infants less than 6 weeks
While less risk of interaction compared to other macrolides, several potential CYP450 interactions may occur; consult a pharmacist for for more details.
Avoid concurrent use with other drugs that prolong QTc
Monitor for signs or symptoms of infantile hypertrophic pyloric stenosis (IHPS) if infant under 6 weeks of life.
Azithromycin is still the drug of choice for treatment or prophylaxis of pertussis as the risk of developing severe pertussis outweighs the potential risk of IHPS.
Concentration: 40 mg/mL
Taste: Bitter taste
Not all strengths of oral liquids are listed nor be available on the CHEO Formulary
250 mg
600 mg
Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.
