Spectrum of Activity


General Information

  • GI symptoms common- especially nausea/vomiting and metallic taste
  • Neurologic side effects including peripheral/optic neuropathy, aseptic meningitis and encephalopathy
  • Disulfiram-like reaction (severe vomiting)

Disulfiram reaction wtih alcohol or alcohol-containing medications/products.

May enhance the QT prolongation of drugs which are known to prolong the QT interval

May increase the serum concentation of vitamin K antagonists (warfarin)

  • Treatment of C. difficile colitis
  • Treatment of infections or abscesses where bowel anaerobes are major pathogens in combination with another agent for aerobic bacteria
  • Empiric treatment of brain abscess in combination with cefotaxime or ceftriaxone

Concentration: 50 mg/mL

Taste: Unpleasant taste

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

  • 250 mg

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.