Aminoglycosides may potentiate nephrotoxicity
Use caution and increase monitoring of renal function when used with concomitant nephrotoxins.
When checking trough level, administer next dose as scheduled. Do not wait for levels to be reported unless otherwise advised.
Serum Level: PRE level 0 to 30 minutes before dose
Initial Level: Prior to fourth or fifth dose
PRE (Trough) levels:
POST (Peak): Not routine. This will be needed if AUC/MIC will be calculated.
Serum creatinine with PRE level once weekly. If targeted levels >10 mg/L, consider more frequent monitoring Patients recieving > 7 days of therapy should have a weekly CBC to assess for neutropenia.
Concentration: 50 mg/mL
Taste: Metallic taste
Not all strengths of oral liquids are listed nor be available on the CHEO Formulary
Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.