Manage predisposing factors: elevate the limb, treat edema, treat tinea pedis, arrange wound care
Often takes 48-72h+ before improvements in erythema/edema
5-10 days depending on response
OR
IV route for patients with systemic signs of infection
Gram negative coverage not necessary unless specific risk factors
Injury occurring in water (Aeromonas - fresh, Vibrio spp. - salt)
Penetrating injury with foreign body (i.e. nail through shoe)
Diabetic foot infection
Immunocompromise
ALSO CONSIDER
Penicillin monotherapy may be used (oral or IV depending on severity) if the findings are highly suggestive of erysipelas