Antimicrobials
Oseltamivir

Oseltamivir

C difficile risk
None
Oral Bioavailability
Excellent
Cost
$8/day

Dosing

75mg PO BID x 5 days or longer in selected patients i.e. immunocompromised, critically ill

Prophylaxis dose 75mg PO daily

10 - 30 eGFR30+ eGFR75mg PO daily75mg PO BID

30mg PO load then 30mg PO after each HD session for 5 day period

75mg PO q24h

General Information

Treatment and prophylaxis of influenza

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No significant

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID

Antimicrobial class: Antiviral - neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2.0

Lung penetration: Therapeutic